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This consists of basic building blocks linked together to form a large macromolecule. Each basic unit contains the two linked aminosugars N-acetylglucosamine and N-acetylmuramyl acid; the latter bears a peptide chain. The building blocks are synthesized in the bacterium, transported outward through the cell membrane, and assembled as illustrated schematically.
At the start of therapy, unwanted reactions occur frequently in the form of a throbbing headache, probably caused by dilation of cephalic vessels. This effect also exhibits tolerance, even when daily “nitrate pauses” are kept. Excessive dosages give rise to hypotension, reflex tachycardia, and circulatory collapse. |
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